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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be valid and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policymakers and 프라그마틱 정품 practitioners to help guide their decisions. They can also be a great method of determining the causal relationship between the intervention and its effects. However, they shouldn't be used as a substitute for the use of explanation trials.

The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis and pragmatic trials that inform the practice and 무료 프라그마틱 - wikimapia.Org, policy decisions. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the features of a practical trial, including the recruitment process, 무료슬롯 프라그마틱 the design and delivery of the intervention, and follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary-care settings.